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代表性成果

1. Liu M*, Ji MJ*, Cheng JH, Li Y, Tian YP, Zhao H, Wang Y, Zhu S, Zhang LL, Xu XM, Feng GS, Liang XH, Bao HL, Tang YD, Kong SB, Lu JH, Wang HB#, Lu ZX# and Deng WB#. Deciphering an critical role of uterine epithelial SHP2 in parturition initiation at single cell resolution. Nat Commun, 2023.
2. Zhao H*, Wang Y*, Xu H*, Liu M, Xu X, Zhu S, Liu Z, Cai H, Wang Y, Lu J, Yang X, Kong S, Bao H#, Wang H#, Deng W#. Stromal cells-specific retinoic acid determines parturition timing at single-cell and spatial-temporal resolution. iScience, 2023
3. Liu M*, Deng W*, Tang L, Liu M, Bao H, Guo C, Zhang, Lu J, Wang H*, Lu Z*, Kong S*. Menin directs regionalized decidual transformation through epigenetically setting PTX3 as an obstacle balancing FGF and BMP signaling. Nat Commun, 2022.
4. Huang P, Deng W*, Bao H, Lin Z, Liu M, Wu J, Zhou X, Qiao M, Yang Y, Cai H, Rao F, Chen J, Chen D, Lu J, Wang H, Qin A, Kong S. SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization. Elife. 2022 Mar 4;11:e72073. doi: 10.7554/eLife.72073.
5. Lv H, Zhao G, Jiang P, Wang H, Wang Z, Yao S, Zhou Z, Wang L, Liu D, Deng W#, Dai J,# Hu Y#. Deciphering the endometrial niche of human thin endometrium at single-cell resolution. Proc Natl Acad Sci U S A. 2022
6. Du L*, Deng W*, Zeng S, Xu P, Huang L, Liang Y, Wang Y, Xu H, Tang J, Bi S, Zhang L, Li Y, Ren L, Lin L, Deng W, Liu M, Chen J, Wang H, Chen D.Single-cell transcriptome analysis reveals defective decidua stromal niche attributes to recurrent spontaneous abortion. Cell Prolif. 2021
7. Deng WB*, Yuan J*, Cha JY, Sun XF, Bartos A, Yagita H, Hirota Y, Dey SK. Endothelial cells in the decidual bed are potential therapeutic targets for preterm birth prevention. Cell Reports. 2019 May
8. Jia Yuan*, Shizu Aikawa*, Wenbo Deng*, Amanda Bartos, Gerd Walz, Florian Grahammer, Tobias B Huber, Xiaofei Sun, Sudhansu K Dey. Primary Decidual Zone Formation Requires Scribble for Pregnancy Success in Mice. Nat Commun, 10(1),5425. 2019 Nov 28.
9. Shizu Aikawa*, Wenbo Deng*, Xiaohuan Liang, Jia Yuan, Amanda Bartos, Xiaofei Sun, Sudhansu K Dey, Uterine Deficiency of High-Mobility Group box-1 (HMGB1) Protein Causes Implantation Defects and Adverse Pregnancy Outcomes, Cell Death Differ, 2019 Oct 8.
10. Wei Lei, Tingting Feng, Xing Fang, You Yu, Junjie Yang, Zhen-Ao Zhao, Junwei Liu, Wenbo Deng#, Shijun Hu#. Signature of circular RNAs in human induced pluripotent stem cells and derived cardiomyocytes. Stem Cell Res Ther. 2018 Mar 9.
11. Yuan J*, Wenbo Deng*, Cha J, Xiaofei Sun, Jean-Paul Borg, Dey SK. Tridimensional visualization reveals direct communication between the embryo and glands critical for implantation. Nat Commun. 2018 Feb 9;9(1):603.
12. Deng WB*, Cha J*, Yuan J, Haraguchi H, Bartos A, Leishman E, Viollet B, Bradshaw HB, Hirota Y, Dey SK. p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing. J Clin Invest. 2016 Aug 1;126(8):2941-54.
13. Deng WB, Liang XH, Liu JL, Yang ZM. Regulation and function of deiodinases during decidualization in female mice. Endocrinology. 2014. 155(7):2704-17.
14. Deng WB, Tian Z, Liang XH, Wang BC, Yang F, Yang ZM. Progesterone regulation of Na/K-ATPase β1 subunit expression in the mouse uterus during the peri-implantation period. Theriogenology. 2013. 79(8):1196-203. (F1000Prime Recommended).

所有论文列表:

• Liu M*, Ji MJ*, Cheng JH, Li Y, Tian YP, Zhao H, Wang Y, Zhu S, Zhang LL, Xu XM, Feng GS, Liang XH, Bao HL, Tang YD, Kong SB, Lu JH, Wang HB#, Lu ZX# and Deng WB#. Deciphering an critical role of uterine epithelial SHP2 in parturition initiation at single cell resolution. Nat Commun, 2023.
• Zhao H*, Wang Y*, Xu H*, Liu M, Xu X, Zhu S, Liu Z, Cai H, Wang Y, Lu J, Yang X, Kong S, Bao H#, Wang H#, Deng W#. Stromal cells-specific retinoic acid determines parturition timing at single-cell and spatial-temporal resolution. iScience, 2023
• Huang P, Deng W, Bao H, Lin Z, Liu M, Wu J, Zhou X, Qiao M, Yang Y, Cai H, Rao F, Chen J, Chen D, Lu J, Wang H, Qin A, Kong S. SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization. Elife. 2022 Mar 4;11:e72073. doi: 10.7554/eLife.72073.
• Liu M‡, Deng W ‡, Tang L, Liu M, Bao H, Guo C, Zhang, Lu J, Wang H*, Lu Z*, Kong S*. Menin directs regionalized decidual transformation through epigenetically setting PTX3 as an obstacle balancing FGF and BMP signaling. Nat Commun, 2022.
• Lv H, Zhao G, Jiang P, Wang H, Wang Z, Yao S, Zhou Z, Wang L, Liu D, Deng W#, Dai J,# Hu Y#. Deciphering the endometrial niche of human thin endometrium at single-cell resolution. Proc Natl Acad Sci U S A. 2022
• Du L*, Deng W*, Zeng S, Xu P, Huang L, Liang Y, Wang Y, Xu H, Tang J, Bi S, Zhang L, Li Y, Ren L, Lin L, Deng W, Liu M, Chen J, Wang H, Chen D.Single-cell transcriptome analysis reveals defective decidua stromal niche attributes to recurrent spontaneous abortion. Cell Prolif. 2021
• Zhou X, Xu Y, Ren S, Liu D, Yang N, Han Q, Kong S, Wang H, Deng W, Qi H, Lu J.Single-cell RNA-seq revealed diverse cell types in the mouse placenta at mid-gestation. Exp Cell Res. 2021
• Zhou C, Lv M, Wang P, Guo C, Ni Z, Bao H, Tang Y, Cai H, Lu J, Deng W, Yang X, Xia G, Wang H, Wang C, Kong S. Sequential activation of uterine epithelial IGF1R by stromal IGF1 and embryonic IGF2 directs normal uterine preparation for embryo implantation. J Mol Cell Biol. 2021
• Deng WB*, Yuan J*, Cha JY, Sun XF, Bartos A, Yagita H, Hirota Y, Dey SK. Endothelial cells in the decidual bed are potential therapeutic targets for preterm birth prevention. Cell Reports. 2019 May
• Jia Yuan*, Shizu Aikawa*, Wenbo Deng*, Amanda Bartos, Gerd Walz, Florian Grahammer, Tobias B Huber, Xiaofei Sun, Sudhansu K Dey. Primary Decidual Zone Formation Requires Scribble for Pregnancy Success in Mice. Nat Commun, 10(1),5425. 2019 Nov 28.
• Shizu Aikawa*, Wenbo Deng*, Xiaohuan Liang, Jia Yuan, Amanda Bartos, Xiaofei Sun, Sudhansu K Dey, Uterine Deficiency of High-Mobility Group box-1 (HMGB1) Protein Causes Implantation Defects and Adverse Pregnancy Outcomes, Cell Death Differ, 2019 Oct 8.
• Jeeyeon Cha, Wenbo Deng, Jia Yuan, Sudhansu K Dey. Aspects of Rodent Implantation, Encyclopedia of Reproduction. 2018 Aug 1.
• Wei Lei, Tingting Feng, Xing Fang, You Yu, Junjie Yang, Zhen-Ao Zhao, Junwei Liu, Wenbo Deng#, Shijun Hu#. (co-corresponding author). Signature of circular RNAs in human induced pluripotent stem cells and derived cardiomyocytes. Stem Cell Res Ther. 2018 Mar 9.
• Yuan J*, Wenbo Deng*, Cha J, Xiaofei Sun, Jean-Paul Borg, Dey SK. Tridimensional visualization reveals direct communication between the embryo and glands critical for implantation. Nat Commun. 2018 Feb 9;9(1):603.
• Deng WB*, Cha J*, Yuan J, Haraguchi H, Bartos A, Leishman E, Viollet B, Bradshaw HB, Hirota Y, Dey SK. p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing. J Clin Invest. 2016 Aug 1;126(8):2941-54.
• Yuan J, Cha J, Deng WB, Bartos A, Sun X, Ho HH, Borg JP, Yamaguchi TP, Yang Y, Dey SK. Planar cell polarity signaling in the uterus directs appropriate positioning of the crypt for embryo implantation. Proc Natl Acad Sci U S A. 2016 Dec 13;113(50):
• Sun X, Deng WB, Li Y, Tang S, Leishman E, Bradshaw HB, and Dey, SK. Sustained Endocannabinoid Signaling Compromises Decidual Function and Promotes Inflammation-induced Preterm Birth. J Biol Chem. 2016a, 291, 8231-8240.
• Sun X, Park CB, Deng WB, Potter SS, and Dey SK. Uterine inactivation of muscle segment homeobox (Msx) genes alters epithelial cell junction proteins during embryo implantation. FASEB J. 2016b. 30, 1425-1435.
• Deng WB, Liang XH, Liu JL, Yang ZM. Regulation and function of deiodinases during decidualization in female mice. Endocrinology. 2014. 155(7):2704-17.
• Liang XH, Deng WB, Li M, Zhao ZA, Wang TS, Feng XH, Cao YJ, Duan EK, and Yang ZM. Egr1 acts downstream of estrogen-LIF-Stat3 pathway and plays a role during implantation through targeting Wnt4. J Biol Chem. 2014. July 10 doi:10.1074/jbc.M114.588897
• Xu X, Leng JY, Gao F, Zhao ZA, Deng WB, Liang XH, Zhang YJ, Zhang ZR, Li M, Sha AG, Yang ZM. Differential expression and anti-oxidant function of glutathione peroxidase 3 in mouse uterus during decidualization. FEBS Lett. 2014. 588(9):1580-9.
• Huang Z, Wang TS, Zhao YC, Zuo RJ, Deng WB, Chi YJ, Yang ZM. Cyclic adenosine monophosphate-induced argininosuccinate synthase 1 expression is essential during mouse decidualization. Mol Cell Endocrinol. 2014. 388(1-2):20-31.
• Rengaraj D, Hwang YS, Liang XH, Deng WB, Yang ZM, Han JY. Comparative expression and regulation of TMSB4X in male reproductive tissues of rats and chickens. J Exp Zool A Ecol Genet Physiol. 2013. 319(10):584-95.
• Zhang XH, Liang X, Wang TS, Liang XH, Zuo RJ, Deng WB, Zhang ZR, Qin FN, Zhao ZA, Yang ZM. Heparin-binding epidermal growth factor-like growth factor (HB-EGF) induction on Snail expression during mouse decidualization. Mol Cell Endocrinol. 2013. 381(1-2):272-9.
• Zhang XH, Liang X, Liang XH, Wang TS, Qi QR, Deng WB, Sha AG, Yang ZM. The mesenchymal-epithelial transition during in vitro decidualization. Reprod Sci. 2013. 20(4):354-60.
• Deng WB, Tian Z, Liang XH, Wang BC, Yang F, Yang ZM. Progesterone regulation of Na/K-ATPase β1 subunit expression in the mouse uterus during the peri-implantation period. Theriogenology. 2013. 79(8):1196-203. (F1000Prime Recommended).
• Lei W, Feng XH, Deng WB, Ni H, Zhang ZR, Jia B, Yang XL, Wang TS, Liu JL, Su RW, Liang XH, Qi QR, Yang ZM.Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice. J Biol Chem. 2012 May 4;287(19):15174-92. doi: 10.1074/jbc.M111.308023.
• Zhao ZA, Zhang ZR, Xu X, Deng WB, Li M, Leng JY, Liang XH, Yang ZM.Arachidonic acid regulation of the cytosolic phospholipase A 2α/cyclooxygenase-2 pathway in mouse endometrial stromal cells. Fertil Steril. 2012 May;97(5):1199-205.e1-9. doi: 10.1016/j.fertnstert.2012.02.011.
• Su RW, Jia B, Ni H, Lei W, Yue SL, Feng XH, Deng WB, Liu JL, Zhao ZA, Wang TS, Yang ZM.Junctional adhesion molecule 2 mediates the interaction between hatched blastocyst and luminal epithelium: induction by progesterone and LIF. PLoS One. 2012;7(4):e34325. doi: 10.1371/journal.pone.0034325.
• Liang XH, Zhao ZA, Deng WB, Tian Z, Lei W, Xu X, Zhang XH, Su RW, Yang ZM.Estrogen regulates amiloride-binding protein 1 through CCAAT/enhancer-binding protein-beta in mouse uterus during embryo implantation and decidualization. Endocrinology. 2010 Oct;151(10):5007-16. doi: 10.1210/en.2010-0170.
• Diao HL, Su RW, Tan HN, Li SJ, Lei W, Deng WB, Yang ZM. Effects of androgen on embryo implantation in the mouse delayed-implantation model. Fertil Steril. 2008 Oct;90(4 Suppl):1376-83.
• Rengaraj D, Liang XH, Gao F, Deng WB, Mills N, Yang ZM. Differential expression and regulation of integral membrane protein 2b in rat male reproductive tissues. Asian J Androl. 2008 May;10(3):503-11.
• Sun T, Deng WB, Diao HL, Ni H, Bai YY, Ma XH, Xu LB, Yang ZM. Differential expression and regulation of prostaglandin E synthases in the mouse ovary during sexual maturation and luteal development. J Endocrinol. 2006 Apr;189(1):89-101.